Author – Jon Russell
Edited by Noah Persin
Welcome back to the GreenSea “Understanding Cannabinoids” series. We’ve covered the “Big 6” cannabinoids: CBGa, CBG, THC, THCv, CBD & CBC. We now move onward to the last two of the most well-known cannabinoids.
Cannabidivarin (CBDv) & Cannabinol (CBN)
Since we covered THCv last we’ll begin with CBDv. Identified in 1969, there is still very little known about CBDv due to the lack of research stemming from cannabis’ legal standing. Here’s what we do know.
First, it’s an analog, or cousin, of CBD and provides many of the same benefits as CBD. They’re both considered non-psychoactive and won’t give you that “stoned” feeling. It’s such a close cousin that they both bind to the TRPV1 receptors, which can assist in mitigating actual levels of pain felt. This receptor is also known to help stabilize motor control.
See how close the two are?
Because CBDv binds to the TRPV1 receptor it is being studied as a potential treatment for epilepsy and seizures. As a matter of fact, GW Pharmaceuticals holds a US patent for the use of CBDv for the treatment of epilepsy. The University of Reading in London also published a study that showed that both CBD and CBDv work well for this treatment in animals and they are working towards human trials. Another study conducted in Ontario, Canada found that CBDv may have a therapeutic potential in reducing nausea as well. This can be beneficial for cancer patients undergoing chemotherapy.
The last of the cannabinoids that has begun any significant clinical research is Cannabinol, or CBN. As THCa and THC oxidizes (is exposed to oxygen) the molecules break down and 4 of the hydrogen atoms break off. This typically happens due to improper storage of cannabis during the curing phase.
CBN is best known for having a highly sedative, or “couch-lock” effect. According to research from Steep Hill Labs, 5mg of CBN is as effective as 10 mg dose of diazepam (a well known mild sedative). This makes it a popular sleep aid for those who suffer from insomnia but are sensitive to chemical medications.
CBN is only mildly psychoactive. It’s so mild that many people believed that it was a non-psychoactive cannabinoid until recently. Steep Hill Labs also found it to help reduce ocular pressure. This means that in some cases it can be (and is) used to treat glaucoma without the effects of THC. According to an Italian study conducted in 2008 CBN is also potentially useful for treating MRSA and other bacterial agents.
CBDv and CBN are the last of the researched cannabinoids in our series. Most of the research has been conducted on THC and CBD and we are left with very little known about the other cannabinoids. With legalization efforts more research will be conducted. New extraction techniques are making it possible to get capsules or edibles that focus on a specific treatment and then the sky’s the limit!
Join us next week for our next article in the “Understanding Cannabinoids” series. We’ll cover a few stray cannabinoids and terpenes. Stay connected for the next in our series by signing up for the newsletter below.
Click here to read the next article in the Understanding Cannabinoid series: CBL, Δ8-THC & Terpenes
CBDV: CANNABIDIVARIN CANNABINOID PROFILE, Whaxy, https://www.whaxy.com/learn/what-is-cbdv-cannabidivarin
Study: Cannabidivarin (CBDV) May Help Treat Epileptic Seizures, Medical Jane, https://www.medicaljane.com/2014/08/13/study-cannabidavarin-cbdv-may-help-treat-epileptiform-seizures/
The Other Cannabinoids: CBD and CBDv, Freedom Leaf, http://www.freedomleaf.com/advanced-cannabis-science-cannabinoids-cbd-cbdv/
Cannabinoids Show Potential in Reducing Nausea, Medical Jane, https://www.medicaljane.com/2013/09/03/cannabinoids-show-potential-in-reducing-nausea/
CBN: The Cannabinoid That Makes You Sleepy, Medical Jane, https://www.medicaljane.com/2013/08/19/cannabinol-cbn-will-put-you-to-bed/
CBN: A Sleeping Synergy, Steep Hill Labs, http://steephilllab.com/cbn-a-sleeping-synergy/